Pharmacokinetics of thrombin ka Agkistrodon acutus ee jiirka

Haemocoagulase Acutus (Halase), heerkulbeeg cusub oo horumarinta halase, waa thrombobin oo kale sida enzyme (TLE) oo ka soo jeeda sunta maska ​​ee Agkistrodon acutus Si loo barto farmashiyaha Halase, 125Ⅰ-ku calaamadsan radioisotope habka iyo radioassay oo lagu daray TCA precip-itate ayaa lagu dabaqay jiirka.Natiijooyinku waxay muujiyeen in qiyamka AUC ay si togan ula xidhiidheen qiyaasaha labada hab ee la isticmaalay, iyo isku xidhka isku xidhku waxay ahaayeen 0.999 8 iyo 0.999 0 siday u kala horreeyaan;Isku-duubnaanta maandooriyaha ee beerka, beeryarada iyo wadnaha ayaa gaadhay heerkii ugu sarreeyay ka dib markii la maamulay 5 daqiiqo halka inta badan xubnaha kale ee kale ay ku gaadheen 30 daqiiqo, ka dibna tartiib tartiib tartiib tartiib ah;wakhti kasta, xooga saarista dawada beerka ayaa si aad ah uga sareysa tan unugyada kale;Halase gabi ahaanba waa laga soo saaray oo inta badan kaadida.% Thrombin ka Agkistrodon acutus waa nooc ka mid ah thrombin go'doonsan oo laga sifeeyey sunta Agkistrodon acutus.Waa nooc cusub oo dawada hemostatic ah oo ay soo saareen kooxdayada Farmashiyaha ee thrombin ka Agkistrodon acutus ee jiirka ayaa lagu bartay 125 I-labeled radioisotope method iyo roobab trichloroacetic acid oo ay weheliso ogaanshaha shucaaca.Natiijooyinku waxay muujiyeen in qiyamka AUC ee lagu qiyaasay labada hab ay si togan ula xiriireen qiyaasta, iyo isku-xirnaanta isku-xirnaanta waxay ahaayeen 0.9998 iyo 0.9990, siday u kala horreeyaan;Maaddooyinka daroogada ee beerka, beeryarada iyo wadnaha ayaa ahaa 5 min ugu sarreeya ka dib maamulka, halka inta badan unugyada kale ay ahaayeen ugu sarreeya 30 min ka dib maamulka, ka dibna si tartiib tartiib ah hoos u dhacay;Waqti kasta, maadada daroogada ee unugyada beerka ayaa si aad ah uga sarreysa tan unugyada kale;Intaa waxaa dheer, soo saarista thrombin ee Agkistrodon acutus waa dhameystiran yahay, inta badan kaadida