Machadka Sunta Maska iyo Qaniinyada Snakebite, Kulliyadda Caafimaadka ee Koonfurta Anhui
Machadka Cilmi-baarista ee Magaalada Wuhu, Gobolka Anhui
Cilmi-baadhista sunta abeesada iyo dhaawaca maska ee Kulliyada Caafimaadka ee Koonfurta Anhui waxay bilaabatay bartamihii 1970-meeyadii, waxayna xubin ka ahayd Kooxda Iskaashiga Daawaynta Dhaawaca Maska ee Gobolka Anhui wakhtigaas.Waa mid ka mid ah hay'adaha ugu horreeya ee sameeya cilmi-baaris aasaasi ah oo la dabaqay oo ku saabsan sunta masska ee Shiinaha.
Magaca Shiinaha
Machadka Sunta Maska iyo Qaniinyada Snakebite, Kulliyadda Caafimaadka ee Koonfurta Anhui
meel
Gobolka Anhui
nooca
dugsiga sare
walax
Sunta Mas iyo Dhaawaca Maska
Guulaha cilmi-baarista ee Machadka
Hordhaca Machadka
Cilmi-baadhista sunta abeesada iyo dhaawaca maska ee Kulliyada Caafimaadka ee Koonfurta Anhui waxay bilaabatay bartamihii 1970-meeyadii, waxayna xubin ka ahayd Kooxda Iskaashiga Daawaynta Dhaawaca Maska ee Gobolka Anhui wakhtigaas.Sannadkii 1984kii, oo uu hoggaaminayey Professor Wen Shangwu, oo ah agaasimaha waaxda waxbaridda iyo cilmi-baadhista ee ardaydii asalka ahayd ee buka, ayaa la aasaasay Xafiiska Cilmi-baadhista Sunta Maska iyo Qaniinyada Maska, taas oo ah mid ka mid ah machadyadii ugu horreeyay ee lagu sameeyo cilmi-baaris aasaasi ah oo la dabaqay. sunta masaska ee Shiinaha.Sannadkii 2007dii, Xafiiska Cilmi-baadhista Sunta Maska iyo Qaniinyada Maska waxa loo beddelay Machadka Cilmi-baadhista Sunta Maska ee Kuliyadda Caafimaadka ee Koonfurta Anhui, agaasimaha hadda waa Professor Zhang Genbao.30-kii sano ee la soo dhaafay, guulaha cilmi-baarista aasaasiga ah iyo kuwa lagu dabaqay ee sunta sunta sunta ee koonfurta Anhui waxay sameeyeen tabarucyo muhiim ah oo ka hortagga iyo xakamaynta dhaawacyada masaska iyo isticmaalka kheyraadka sunta masaska ee Shiinaha;Masaska sunta ah ee koonfurta Anhui waa Agkistrodon acutus (Agkistrodon acutus), Agkistrodon acutus, Cobra, Green Bamboo Leaf Snake, Chromium Iron Head iyo Bungarus multicinctus, gaar ahaan Agkistrodon acutus, oo si weyn u saameeya caafimaadka iyo nolosha dadka buuraleyda ah.Daraasaduhu waxay muujiyeen in masaska sunta ah ay inta badan soo saaraan sunta wareegga dhiigga iyo neurotoxins, taas oo keeni karta bukaanada inay la kulmaan faafinta xinjirowga xididdada dhiigga (DIC) iyo dhiig-bax labaad, shoog, xubno badan oo hawlgab ah iyo cawaaqib kale oo halis ah;Iyada oo loo marayo daraasad nidaamsan oo ku saabsan sunta sunta dhiigga ee sunta Agkistrodon acutus (Agkistrodon acutus) ee koonfurta Anhui, ayaa la ogaaday in DIC ee la xidhiidha qaniinyada abeesada ay tahay mid ka mid ah calaamadaha dabiiciga ah ee sumowga hore, waxayna ka duwan tahay DIC ee lagu muujiyay dhaqameed. aragtiyo.Sidaa darteed, fikradda "DIC like" syndrome ee bukaannada uu qaniinay Agkistrodon acutus ayaa markii ugu horreysay lagu soo jeediyay Shiinaha (1988), Waxa kale oo la aqoonsaday in thrombin sida enzyme (TLE) iyo fibrinolytic enzyme (FE) ay ku jiraan sunta Agkistrodon acutus. Sababaha ugu waaweyn ee kan "DIC like" (1992).Tani waxay muhiimad weyn u leedahay in la caddeeyo sifooyinka isbeddelka dhiigga ee bukaanka Agkistrodon acutus, iyo sidoo kale waxay bixisaa saldhig aragtiyeed oo loogu talagalay codsiga antivenomi gaar ah si loo daaweeyo dhibaatadan.Daraasad ku saabsan habka dhiig-baxa ee uu keeno Agkistrodon acutus venom, ayaa sidoo kale lagu ogaaday in suntan masku ay saameyn ku leedahay saddexda qaybood ee ugu waaweyn habdhiska dhiig-baxa (calaamadaha xinjirowga, platelets iyo derbiyada xididdada dhiigga), kuwaas oo hemotoxin ay si toos ah u yihiin. waxay saamaysay qulqulka xididada.Isla mar ahaantaana, waxaa la ogaaday in dhiig-baxa halista ah ee uu keeno sunta sunta Agkistrodon acutus iyo dhibka bararka xubnaha dhaawaca ah si ay u yaraato ay la xiriirto xannibaadda dheecaanka dheecaanka leh ee xinjirowga dhiigga ee xuubka xuubka iyo heerka qulqulka limfa ee liita.Guulahaan aasaasiga ah iyo kuwa la dabaqay ee cilmi-baarista aasaasiga ah waxay door muhiim ah ka ciyaareen iskaashiga muddada fog ee Machadka Cilmi-baarista ee Qimen Snakebite si wax ku ool ah u dejiyaan qorshaha daaweynta qaniinyada masaska iyo hubinta badbaadada bukaanka qaniinyada masaska, waxayna ku guuleysteen saameyn bulsho oo muhiim ah.Guulaha cilmi-baarista waxay si isdaba-joog ah ugu guuleysteen Abaalmarinta Horumarka Sayniska iyo Tignoolajiyada ee Gobolka Anhui, Abaalmarinta Horumarka Sayniska iyo Tignoolajiyada ee Gobolka Anhui (1993), iyo (A) Heerka Sayniska iyo Horumarka Tignoolajiyada Abaalmarinta Wadajirka ah ee Wasaaradda Caafimaadka (1991);1989kii, waxay la kaashatay Machadka Wuhan ee Alaabooyinka Bayoolojiga si ay u horumariyaan antibody monoclonal ka hortagga thrombin sida enzim ee Agkistrodon acutus venom, taas oo ahayd guushii ugu horeysay ee Shiinaha;1996, waxay si wadajir ah u soo saartay oo ay u samaysay alaabada thrombin (YWYZZ 1996 No. 118004, patent CN1141951A) oo leh Machadka Bayoolojiga iyo Dawooyinka ee Gobolka Militariga Jinan.
natiijooyinka cilmi-baarista
Sanadihii la soo dhaafay, shaybaarku waxa uu kala soocay oo nadiifiyay noocyo kala duwan oo walxo noole ah oo ka yimid sunta cayriin ee Agkistrodon acutus, Agkistrodon halys iyo Cobra ee koonfurta Anhui, sida enzymes-ka gobolka ee ka hortagga hypercoagulable, protein C activators (PCA).Daraasadaha tijaabada ah ayaa xaqiijiyay in maaddooyinkan firfircooni ay saameyn ku yeelan karaan habka xinjirowga, saameyn ku yeelan karaan adhesion platelet, isu-ururinta iyo ilaalinta shaqada unugyada xuubka xididdada dhiigga, waxayna leeyihiin waxtar sare iyo hoos u dhigista sunta xinjirowga lidka ku ah iyo saameynta thrombolytic, Tani waxay muhiimad weyn u leedahay ka hortagga iyo daaweynta. cudurada thrombotic iyo hagaajinta hypercoagulability ee dhiigga;Isla mar ahaantaana, waxaa sidoo kale la ogaaday in PCA-ga sunta abeesada ay leedahay saameyn gaar ah oo lagu dilayo unugyada leukemia-ga ee K562 iyo in la joojiyo metastasis-ka unugyada kansarka.Rajada codsiga caafimaad waa mid aad u ballaaran.Xafiiska cilmi baadhistu waxa uu si isdaba joog ah u qabtay oo uu dhamaystiray mashaariic badan oo cilmi baadhis ah, sida "Mechanism of DIC ay sababtay Agkistrodon acutus venom", "Cilmi-baadhis ku saabsan habka dhiig-baxa ee uu keeno Agkistrodon acutus venom ee xayawaanka", "Baaritaanka qaniinyada masska iyo kala duwanaanshaha ogaanshaha qoyska abeesada habka calaamadaynta enzim", oo ay maalgelisay Hay'adda Sayniska Dabiiciga ah ee Qaranka, Wasaaradda Caafimaadka, Waaxda Caafimaadka iyo Waaxda Waxbarashada ee Gobolka Anhui;Waqtigan xaadirka ah, mashaariicda lagu horumarinayo waxaa ka mid ah: "Cilmi-baaris ku saabsan Protein Anticoagulant Hemorrhagic Anticoagulant ee Agkistrodon acutus", "Cilmi-baaris ku saabsan Farsamada Molecular ee Saamaynta PCA ee Agkistrodon halys Pallas Venom ee Shaqada Endothelial Vascular", "Cilmi-baaris ku saabsan Biology-ga Molecular PCA-ga Agkistrodon acutus Venom lidka ku ah Unugyada Burada”, iyo Kala saarida iyo Nadiifinta Qaybaha Daweynta Dareemaha ee Venom Cobra.
Machadka cilmi baarista sunta maska ee South Anhui Medical College wuxuu leeyahay shuruudo aasaasi ah oo wanaagsan, qalab cilmi baaris oo dhameystiran, qaab dhismeedka kooxda cilmi-baarista macquulka ah, iyo horumarka joogtada ah ee hababka cilmi baarista iyo hababka farsamada.Waxa la filayaa in ay guulo cusub ka gaadho cilmi baadhista sayniska, tababarka shaqaalaha, iwmFarmashiyaha sunta abeesada waa daroogo leh xuquuqda lahaanshaha garaadka ee Shiinaha.Natiijooyinka cilmi-baarista ee ku saleysan iyo adeegsiga sunta masaska iyo qaybaha ay ka kooban tahay ayaa muhiimad weyn u leh horumarinta kheyraadka sunta masaska ee koonfurta Anhui iyo codsiga bukaan-socodka.
Waqtiga boostada: Nov-11-2022